Article

SETD2 promotes PAF1C interactions with the elongating RNA Pol II and is required for neuronal differentiation

2024-10-24

Abstract excerpt

Chromatin modifications are relevant for mammalian development and their aberrant deposition is associated with human disease. While the mechanisms that deposit and remove these modifications have been largely elucidated, their role in regulating gene activity during cellular differentiation have yet to be completely understood. By differentiating a panel of mouse embryonic stem cells lacking major chromatin regul...

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Literature Corpus work: f5ce2a1f-92dd-55c3-a313-180eaebb2fe9
DOI: 10.1101/2024.10.23.619798

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