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Article

Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish.

Cells - 12 Nov 2021

Raby Ludivine, Völkel Pamela, Hasanpour Shaghayegh, Cicero Julien, Toillon Robert-Alain, Adriaenssens Eric, Van Seuningen Isabelle, Le Bourhis Xuefen, Angrand Pierre-Olivier

Abstract excerpt

Polycomb repressive complex 2 (PRC2) mediates histone H3K27me3 methylation and the stable transcriptional repression of a number of gene expression programs involved in the control of cellular identity during development and differentiation. Here, we report on the generation and on the characterization of a zebrafish line harboring a null allele of eed, a gene coding for an essential component of the PRC2....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34831364
DOI: 10.3390/cells10113142
PMCID: PMC8620594

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Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish.PMID 34831364Read ↗

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2.Semantic proximity Read ↗

Selective requirement for polycomb repressor complex 2 in the generation of specific hypothalamic neuronal subtypes.Semantic proximity Read ↗

Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowthSemantic proximity Read ↗

Loss of EED in the oocyte causes initial fetal growth restriction followed by placental hyperplasia and offspring overgrowthSemantic proximity Read ↗

Aebp2 as an Epigenetic Regulator for Neural Crest CellsSemantic proximity Read ↗

The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.Semantic proximity Read ↗

EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.Semantic proximity Read ↗

The Polycomb Group Protein Pcgf1 Is Dispensable in Zebrafish but Involved in Early Growth and Aging.Semantic proximity Read ↗

Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.Semantic proximity Read ↗

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.Semantic proximity Read ↗

Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.Semantic proximity Read ↗

The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development.Semantic proximity Read ↗

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