Article

Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype

2023-05-25

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc) . Rit2 is a reported PD risk allele, and recent single cell transcriptomic studies identified a major RIT2 cluster in PD DA neurons, potentially linking Rit2 expression anomalies to a PD patient cohort. However...

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Literature Corpus work: 4c4b9a0e-5535-5866-b367-99a98e021a1c
DOI: 10.21203/rs.3.rs-2944614/v1

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