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Article

Dynamic landscape of chromatin accessibility and transcriptomic changes during differentiation of human embryonic stem cells into dopaminergic neurons.

Scientific reports - 20 Aug 2021

Meléndez-Ramírez César, Cuevas-Diaz Duran Raquel, Barrios-García Tonatiuh, Giacoman-Lozano Mayela, López-Ornelas Adolfo, Herrera-Gamboa Jessica, Estudillo Enrique, Soto-Reyes Ernesto, Velasco Iván, Treviño Víctor

Abstract excerpt

Chromatin architecture influences transcription by modulating the physical access of regulatory factors to DNA, playing fundamental roles in cell identity. Studies on dopaminergic differentiation have identified coding genes, but the relationship with non-coding genes or chromatin accessibility remains elusive. Using RNA-Seq and ATAC-Seq we profiled differentially expressed transcripts and open chromatin regions...

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Identifiers

PMID: 34417498
DOI: 10.1038/s41598-021-96263-1
PMCID: PMC8379280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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