Article

Rit2 silencing in dopamine neurons drives a Parkinsonian phenotype

2023-04-28

Abstract excerpt

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc). Rit2 is a reported PD risk allele, and recent single cell transcriptomic studies identified a major RIT2 cluster in PD DA neurons, potentially linking Rit2 expression loss to a PD patient cohort. However, it is still unknown whether Rit2...

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Literature Corpus work: c9ba6fe9-4af6-5186-9452-0dff3d8a0018
DOI: 10.1101/2023.04.26.538430

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