Article

Mapping the ISR Landscape in Cognitive Disorders <i>via</i> single-cell multi-omics

2025-03-02

Abstract excerpt

<h4>Summary</h4> Persistent activation of the integrated stress response (ISR) is a major driver of cognitive decline in both neurodevelopmental and neurodegenerative disorders. Using a new mouse model ( Ppp1r15b R658C mice) that mimics the persistent ISR activation and cognitive decline observed in humans, we generated the first single-cell ISR atlas of the brain. By integrating single-cell RNA-seq and single-c...

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Literature Corpus work: b51ed3ea-71bf-5aa8-bce9-b38ca614356a
DOI: 10.1101/2025.02.28.640905

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