Article

Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction

2025-03-02

Abstract excerpt

<h4>Summary</h4> The integrated stress response (ISR) is a highly conserved network essential for maintaining cellular homeostasis and cognitive function. Here, we investigated how persistent ISR activation impacts cognitive performance, primarily focusing on a PPP1R15B R658C genetic variant associated with intellectual disability. By generating a novel mouse model that mimics this human condition, we revealed t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7c26ccd-88da-5630-9ea0-0ad5a618d70f
DOI: 10.1101/2025.02.28.640897

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive DysfunctionDOI 10.1101/2025.02.28.640897Read

Mapping the ISR Landscape in Cognitive Disorders <i>via</i> single-cell multi-omicsSemantic proximity Read

Unveiling the crucial neuronal role of the proteasomal ATPase subunit gene<i>PSMC5</i>in neurodevelopmental proteasomopathiesSemantic proximity Read

Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndromeSemantic proximity Read

Histone deacetylase inhibition expands cellular proteostasis repertoires to enhance neuronal stress resilienceSemantic proximity Read

HSF1-mediated Proteostasis Decline Links Aging and Sleep DisruptionSemantic proximity Read

eIF2B activator prevents neurological defects caused by a chronic Integrated Stress ResponseSemantic proximity Read

Prime editing links the split integrated stress response to pathogenic eIF2B mutations and white matter degeneration.Semantic proximity Read

Genetic variation in the Nr1d1 transcription factor binding site shapes metabolism-related protein networks associated with cognitive resilience in an Alzheimer's disease mouse reference panel.Semantic proximity Read

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunitSemantic proximity Read

The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathologySemantic proximity Read

Integrated Stress Response Deregulation underlies Vanishing White Matter and is a target for therapySemantic proximity Read

Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down SyndromeSemantic proximity Read