Article

MR-Clust: Clustering of genetic variants in Mendelian randomization with similar causal estimates

2019-12-19

Abstract excerpt

<h4>Motivation</h4> Mendelian randomization is an epidemiological technique that uses genetic variants as instrumental variables to estimate the causal effect of a risk factor on an outcome. We consider a scenario in which causal estimates based on each variant in turn differ more strongly than expected by chance alone, but the variants can be divided into distinct clusters, such that all variants in the cluster...

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Literature Corpus work: b50192fe-dd0d-5f4f-a4b5-ae60deba8036
DOI: 10.1101/2019.12.18.881326

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