Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A robust and efficient method for Mendelian randomization with hundreds of genetic variants.

Nature communications - 17 Jan 2020

Burgess Stephen, Foley Christopher N, Allara Elias, Staley James R, Howson Joanna M M

Abstract excerpt

Mendelian randomization (MR) is an epidemiological technique that uses genetic variants to distinguish correlation from causation in observational data. The reliability of a MR investigation depends on the validity of the genetic variants as instrumental variables (IVs). We develop the contamination mixture method, a method for MR with two modalities. First, it identifies groups of genetic variants with similar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol, HDL
Share to Cholesterol, LDL
Share to Coronary Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Pleiotropy

Share to Mendelian Randomization Analysis

Share to Molecular Epidemiology

Share to Research Design

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 31953392
DOI: 10.1038/s41467-019-14156-4
PMCID: PMC6969055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A robust and efficient method for Mendelian randomization with hundreds of genetic variants.PMID 31953392Read ↗

A robust and efficient method for Mendelian randomization with hundreds of genetic variants: unravelling mechanisms linking HDL-cholesterol and coronary heart diseaseSemantic proximity Read ↗

A Comparison Of Robust Mendelian Randomization Methods Using Summary DataSemantic proximity Read ↗

Mendelian Randomization Analysis Using Mixture Models (MRMix) for Genetic Effect-Size-Distribution Leads to Robust Estimation of Causal EffectsSemantic proximity Read ↗

A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related DiseasesSemantic proximity Read ↗

Mendelian Randomization Studies in Atherosclerotic Cardiovascular DiseasesSemantic proximity Read ↗

Benchmarking Mendelian randomization methods for causal inference using genome-wide association study summary statistics.Semantic proximity Read ↗

Mendelian randomization for cardiovascular diseases: principles and applicationsSemantic proximity Read ↗

[Mendelian randomization approach, used for causal inferences].Semantic proximity Read ↗

Mendelian Randomization.Semantic proximity Read ↗

Mendelian Randomization with Instrumental Variable Synthesis (IVY)Semantic proximity Read ↗

Sparse Dimensionality Reduction Approaches in Mendelian Randomization with highly correlated exposuresSemantic proximity Read ↗

Using clustering of genetic variants in Mendelian randomization to interrogate the causal pathways underlying multimorbidity from a common risk factor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.