Article

PheWAS-based clustering of Mendelian Randomisation instruments reveals distinct mechanism-specific causal effects between obesity and educational attainment

2023-04-12

Abstract excerpt

Mendelian Randomisation (MR) is a statistical method that estimates causal effects between risk factors and common complex diseases using genetic instruments. Heritable confounders, pleiotropy and heterogeneous causal effects violate MR assumptions and can lead to biases. To tackle these, we propose an approach employing a PheWAS-based clustering of the MR instruments (PWC-MR). We apply this method to revisit the...

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Literature Corpus work: 5df3ae47-9063-5615-b3f5-6af9bda4647b
DOI: 10.1101/2023.04.06.23288264

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