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Article

Estimating and visualising multivariable Mendelian randomization analyses within a radial framework.

PLoS genetics - 1 Dec 2024

Spiller Wes, Bowden Jack, Sanderson Eleanor

Abstract excerpt

BACKGROUND: Mendelian randomization (MR) is a statistical approach using genetic variants as instrumental variables to estimate causal effects of a single exposure on an outcome. Multivariable MR (MVMR) extends this to estimate the direct effect of multiple exposures simulatiously. MR and MVMR can be biased by the presence of pleiotropic genetic variants in the set used as instrumental variables, violating one of...

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Identifiers

PMID: 39680583
DOI: 10.1371/journal.pgen.1011506
PMCID: PMC11684766

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