Article

Using clustering of genetic variants in Mendelian randomization to interrogate the causal pathways underlying multimorbidity

2023-03-23

Abstract excerpt

Mendelian randomization (MR) is an epidemiological approach that utilizes genetic variants as instrumental variables to estimate the causal effect of a modifiable but likely confounded exposure on a health outcome. This paper investigates an MR scenario in which different subsets of genetic variants identify different causal effects. These variants may aggregate into clusters, and such variant clusters are likely...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b86fe1d-27ba-5d53-bcc3-949509ca6dee
DOI: 10.1101/2023.03.18.23287164

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Using clustering of genetic variants in Mendelian randomization to interrogate the causal pathways underlying multimorbidityDOI 10.1101/2023.03.18.23287164Read

Using clustering of genetic variants in Mendelian randomization to interrogate the causal pathways underlying multimorbidity from a common risk factor.Semantic proximity Read

METEOR: a data-adaptive Mendelian randomization method for powerful detection of shared and specific exposures underlying multiple outcomes.Semantic proximity Read

Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesitySemantic proximity Read

Multi-response Mendelian randomization: Identification of shared and distinct exposures for multimorbidity and multiple related disease outcomesSemantic proximity Read

Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity.Semantic proximity Read

Multi-response Mendelian randomization: Identification of shared and distinct exposures for multimorbidity and multiple related disease outcomesSemantic proximity Read

MR-Clust: Clustering of genetic variants in Mendelian randomization with similar causal estimatesSemantic proximity Read

Genome-wide association study of cardiometabolic multimorbidity in the UK Biobank.Semantic proximity Read

Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and SubtypesSemantic proximity Read

A robust and efficient method for Mendelian randomization with hundreds of genetic variants.Semantic proximity Read

Multitrait genetic-phenotype associations to connect disease variants and biological mechanismsSemantic proximity Read

Mendelian Randomization Analysis Using Multiple Biomarkers of an Underlying Common ExposureSemantic proximity Read