Article

Examining the evidence for Mendelian randomization homogeneity assumption violation using instrument association with exposure variance

2022-09-15

Abstract excerpt

<h4>Background</h4> Estimation of the average causal effect using instrumental variable (IV) analyses requires homogeneity of instrument-exposure and/or exposure-outcome relationships. Previous research explored the validity of homogeneity assumptions by testing IV-exposure interaction effects using a set of effect modifiers. However, this approach requires that modifiers are known and measured but evidence for in...

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Literature Corpus work: b4edfc97-88de-5501-93e2-b527fd4c169a
DOI: 10.1101/2022.09.12.22279854

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