Article
A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases
15 Jan 2025
Abstract excerpt
Mendelian randomization (MR) is a statistical method that uses genetic variants as instrumental variables to estimate the causal effect of exposure on an outcome in the presence of unmeasured confounding. In this review, we argue that it is crucial to acknowledge the instrumental variable assumptions in MR analysis. We describe widely used MR methods, using an example from obesity-related metabolic disorders. We...
Topics
Join the communities discussing this publication.