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Article

Falsification of the instrumental variable conditions in Mendelian randomization studies in the UK Biobank.

European journal of epidemiology - 1 Sept 2023

Guo Kelly, Diemer Elizabeth W, Labrecque Jeremy A, Swanson Sonja A

Abstract excerpt

Mendelian randomization (MR) is an increasingly popular approach to estimating causal effects. Although the assumptions underlying MR cannot be verified, they imply certain constraints, the instrumental inequalities, which can be used to falsify the MR conditions. However, the instrumental inequalities are rarely applied in MR. We aimed to explore whether the instrumental inequalities could detect violations of...

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PMID: 37253997
DOI: 10.1007/s10654-023-01003-6
PMCID: PMC10501946

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