Article

Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption

2017-04-10

Abstract excerpt

<h4>Background</h4> Mendelian randomisation (MR) is being increasingly used to strengthen causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association studies (GWAS) allows straightforward application of MR using summary data methods, typically in a two-sample design. In addition to the conventional inverse variance...

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Literature Corpus work: 26fadc20-a9ef-5b28-b43e-79f741ad139b
DOI: 10.1101/126102

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