Article
Mendelian Randomization in Cardiovascular Research: Establishing Causality When There Are Unmeasured Confounders.
Circulation. Cardiovascular quality and outcomes - 1 Jan 2021
Bell Katy J L, Loy Clement, Cust Anne E, Teixeira-Pinto Armando
Abstract excerpt
Mendelian randomization is an epidemiological approach to making causal inferences using observational data. It makes use of the natural randomization that occurs in the generation of an individual's genetic makeup in a way that is analogous to the study design of a randomized controlled trial and uses instrumental variable analysis where the genetic variant(s) are the instrument (analogous to random allocation...
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