Article

Template switching mechanism drives the tandem amplification of chromosome 20q11.21 in human pluripotent stem cells

2020-07-12

Abstract excerpt

Copy number variants (CNVs) are genomic rearrangements implicated in numerous congenital and acquired diseases, including cancer. In human pluripotent stem cells (PSC), the appearance of culture-acquired CNVs prompted concerns for their use in regenerative medicine applications. A particularly common problem in PSC is the occurrence of CNVs in the q11.21 region of chromosome 20. However, the exact mechanisms of or...

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Literature Corpus work: b4e6f8d4-3781-5ef7-b1b7-094839bf233f
DOI: 10.1101/2020.07.11.198382

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