Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture.

doi:10.1016/j.stem.2010.12.003

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Article

Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture.

Cell stem cell - 7 Jan 2011

Laurent Louise C, Ulitsky Igor, Slavin Ileana, Tran Ha, Schork Andrew, Morey Robert, Lynch Candace, Harness Julie V, Lee Sunray, Barrero Maria J, Ku Sherman, Martynova Marina, Semechkin Ruslan, Galat Vasiliy, Gottesfeld Joel, Izpisua Belmonte Juan Carlos, Murry Chuck, Keirstead Hans S, Park Hyun-Sook, Schmidt Uli, Laslett Andrew L, Muller Franz-Josef, Nievergelt Caroline M, Shamir Ron, Loring Jeanne F

Abstract excerpt

Genomic stability is critical for the clinical use of human embryonic and induced pluripotent stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on 186 pluripotent and 119 nonpluripotent samples. We report a higher frequency of subchromosomal copy number variations in pluripotent samples compared to nonpluripotent samples, with variations enriched in specific genomic regions....

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PMID: 21211785
DOI: 10.1016/j.stem.2010.12.003
PMCID: PMC3043464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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