Article

Kynurenic acid promotes activity-dependent synaptic pruning in schizophrenia

2023-10-23

Abstract excerpt

Schizophrenia is a neurodevelopmental disorder characterized by an excessive loss of synapses. Recent data suggest that this is due to increased microglia-mediated synaptic pruning. Here, we utilize human induced pluripotent stem cell-derived models to show that kynurenic acid (KYNA), an endogenous NMDA-receptor antagonist observed to be increased in the brains of individuals with schizophrenia, reduces neuronal a...

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Literature Corpus work: 347bc378-3ea0-5ff3-a495-f9f3416d4d11
DOI: 10.1101/2023.10.19.563090

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