Article

Atypical antipsychotics alter microglial functions via astrocyte-derived extracellular vesicles

2025-06-01

Abstract excerpt

A limited understanding of the underlying molecular mechanisms of atypical antipsychotics has hindered efforts to develop the next generation of treatments for schizophrenia. In particular, there has been little investigation of how medications like clozapine and olanzapine modulate human non-neuronal cells, including astrocytes and microglia. Recent postmortem and serum-based studies suggest that schizophrenia et...

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Literature Corpus work: 78cc0d04-a8b6-564b-bab7-66c6ad8d9850
DOI: 10.1101/2025.05.28.656664

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