Article

Development of stapled peptides targeting the Ral GTPases

2020-01-01

Abstract excerpt

The ras genes are the most commonly mutated oncogenes in human cancers, with mutations occurring in approximately 20% of human tumours. However, more than 30 years of attempts to target Ras proteins therapeutically have yielded no effective therapies in the clinic, leading the proteins to be widely deemed 'undruggable'. In recent years, there has been substantial evidence implicating the Ral GTPases, RalA and RalB...

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Literature Corpus work: b48d5dec-bbf6-5008-8621-b52b4e6e443f
DOI: 10.17863/cam.63944

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