Article

Inhibition of tumor growth by a novel engineered chimeric toxin that cleaves activated mutant and wild-type RAS

2019-12-18

Abstract excerpt

<h4>Summary</h4> Despite nearly four decades of effort, broad inhibition of oncogenic RAS using small molecule approaches has proven to be a major challenge. Here we describe the development of a novel pan-RAS biologic inhibitor comprised of the RAS-RAP1-specific endopeptidase fused to the protein delivery machinery of diphtheria toxin. We show that this engineered chimeric toxin irreversibly cleaves and inactiva...

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Identifiers and source

Literature Corpus work: 9550d389-3975-570a-abff-cb33c683a083
DOI: 10.1101/2019.12.17.880187

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