Article

Identification and characterization of binders to a novel cryptic and functional pocket in KRAS

2024-11-08

Abstract excerpt

<title>Abstract</title> <p>RAS proteins control cell proliferation and activating mutations are collectively the most frequent oncogenic event observed in cancer patients, justifying investments into multiple drug discovery efforts. While RAS-directed therapeutic agents targeting either the inactive GDP-bound or the active GTP-bound state have entered the clinic, invariably resistance is observed. Mutations at dr...

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Literature Corpus work: de84aadb-235f-5913-8c2f-517340da1f68
DOI: 10.21203/rs.3.rs-5354688/v1

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