Article

Competitive Inhibitors of Ras Effector Binding

2019-02-15

Abstract excerpt

The small GTPases H, K and NRas are molecular switches that are indispensable for the correct regulation of cellular proliferation and growth. Mutations in Ras are associated with cancer and result in unwanted activation of signaling processes caused by aberrant recruitment of downstream effector proteins. In this study, we have engineered variants of the Ras-binding domain (RBD) of CRAF kinase that bind with high...

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Literature Corpus work: ccc67720-55ce-5399-9537-6bdd3a5f7b6e
DOI: 10.1101/548750

Open publication

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