Article
SOS1-inspired hydrocarbon-stapled peptide as a pan-Ras inhibitor.
Bioorganic chemistry - 1 Jun 2023
Li Anpeng, Li Xiang, Zou Jihua, Zhuo Xiaobin, Chen Shuai, Chai Xiaoyun, Gai Conghao, Xu Weiheng, Zhao Qingjie, Zou Yan
Abstract excerpt
Blocking the interaction between Ras and Son of Sevenless homolog 1 (SOS1) has been an attractive therapeutic strategy for treating cancers involving oncogenic Ras mutations. K-Ras mutation is the most common in Ras-driven cancers, accounting for 86%, with N-Ras mutation and H-Ras mutation accounting for 11% and 3%, respectively. Here, we report the design and synthesis of a series of hydrocarbon-stapled peptides...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.