Ras and Rap1: A tale of two GTPases.

doi:10.1016/j.semcancer.2018.03.005

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Article

Ras and Rap1: A tale of two GTPases.

Seminars in cancer biology - 1 Feb 2019

Shah Seema, Brock Ethan J, Ji Kyungmin, Mattingly Raymond R

Abstract excerpt

Ras oncoproteins play pivotal roles in both the development and maintenance of many tumor types. Unfortunately, these proteins are difficult to directly target using traditional pharmacological strategies, in part due to their lack of obvious binding pockets or allosteric sites. This obstacle has driven a considerable amount of research into pursuing alternative ways to effectively inhibit Ras, examples of which...

Topics

Animals
Biomarkers, Tumor
Cell Adhesion
Energy Metabolism
Epithelial-Mesenchymal Transition
Gene Expression Regulation, Neoplastic
Humans
Integrins
Molecular Targeted Therapy
Mutation
Neoplasms
Signal Transduction
rap1 GTP-Binding Proteins
ras Proteins

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Identifiers

PMID: 29621614
DOI: 10.1016/j.semcancer.2018.03.005
PMCID: PMC6170734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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