Targeting Ras with protein engineering.

Abstract excerpt

Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated with many types of cancer, making them attractive targets for cancer therapy. Despite extensive efforts, targeting Ras proteins with small molecules has been extremely challenging due to Ras's mostly flat surface and lack of small molecule-binding cavities. These challenges were recently overcome by the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genes, ras
• Share to Mutation
• Share to Neoplasms