Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007--present).

Abstract excerpt

INTRODUCTION: Ras proteins are small GTPases molecular switches that cycle through two alternative conformational states, a GDP-bound inactive state and a GTP-bound active state. In the active state, Ras proteins interact with and modulate the activity of several downstream effectors regulating key cellular processes including proliferation, differentiation, survival, senescence, migration and metabolism....

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