Haplotypes of common SNPs can explain missing heritability of complex diseases

Abstract excerpt

While genome-wide significant associations generally explain only a small proportion of the narrow-sense heritability of complex disease ( h 2 ), recent work has shown that more heritability is explained by all genotyped SNPs ( h g 2 ). However, much of the heritability is still missing ( h g 2 < h 2 ). For example, for schizophrenia, h 2 is estimated at 0.7-0.8 but h g 2 is estimated at ∼0.3. Efforts at in...

Topics

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• Algorithms
• Computer Simulation
• Genetic Predisposition to Disease
• Genotype
• Haplotypes
• Models, Genetic
• Polymorphism, Single Nucleotide
• Schizophrenia

Identifiers and source

Literature Corpus work

b4708b7a-1f75-585c-8b75-20fb7adfb3e5

DOI

10.1101/022418