Subtle stratification confounds estimates of heritability from rare variants

Abstract excerpt

Genome-wide significant associations generally explain only a small proportion of the narrow-sense heritability of complex disease ( h 2 ). While considerably more heritability is explained by all genotyped SNPs ( h g 2 ), for most traits, much heritability remains missing ( h g 2 < h 2 ). Rare variants, poorly tagged by genotyped SNPs, are a major potential source of the gap between h g 2 and h 2 . Recent e...

Topics

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• Algorithms
• Gene Frequency
• Genetic Loci
• Genetic Predisposition to Disease
• Genetic Variation
• Genome-Wide Association Study
• Models, Genetic
• Models, Statistical

Identifiers and source

Literature Corpus work

f1468ccc-6f80-5cd5-bb87-6f85b26ef420

DOI

10.1101/048181