Explaining the missing heritability of psychiatric disorders

Abstract excerpt

Evidence from family, twin and adoption studies indicates that psychiatric disorders are substantially heritable. Heritability is usually expressed as the proportion of trait variance attributable to additive genetic factors (narrow sense heritability: h2). The h2 estimates for schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorder and bipolar disorder are all >0.66, and are substantial...

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