Leveraging haplotype information in heritability estimation and polygenic prediction.

doi:10.1038/s41467-024-55477-3

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Article

Leveraging haplotype information in heritability estimation and polygenic prediction.

Nature communications - 2 Jan 2025

Meisner Jonas, Benros Michael Eriksen, Rasmussen Simon

Abstract excerpt

Polygenic prediction has yet to make a major clinical breakthrough in precision medicine and psychiatry, where the application of polygenic risk scores is expected to improve clinical decision-making. Most widely used approaches for estimating polygenic risk scores are based on summary statistics...

Topics

Humans
Multifactorial Inheritance
Haplotypes
Schizophrenia
Genome-Wide Association Study
Algorithms
Genetic Predisposition to Disease
Models, Genetic
Polymorphism, Single Nucleotide
Computer Simulation
Genotype
Precision Medicine

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