Article
Missing heritability and strategies for finding the underlying causes of complex disease.
Nature reviews. Genetics - 1 Jun 2010
Eichler Evan E, Flint Jonathan, Gibson Greg, Kong Augustine, Leal Suzanne M, Moore Jason H, Nadeau Joseph H
Abstract excerpt
Although recent genome-wide studies have provided valuable insights into the genetic basis of human disease, they have explained relatively little of the heritability of most complex traits, and the variants identified through these studies have small effect sizes. This has led to the important and hotly debated issue of where the 'missing heritability' of complex diseases might be found. Here, seven leading...
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