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Article

A theoretical model for calculating voltage sensitivity of ion channels and the application on Kv1.2 potassium channel.

Biophysical journal - 18 Apr 2012

Yang Huaiyu, Gao Zhaobing, Li Ping, Yu Kunqian, Yu Ye, Xu Tian-Le, Li Min, Jiang Hualiang

Abstract excerpt

Voltage sensing confers conversion of a change in membrane potential to signaling activities underlying the physiological processes. For an ion channel, voltage sensitivity is usually experimentally measured by fitting electrophysiological data to Boltzmann distributions. In our study, a two-state model of the ion channel and equilibrium statistical mechanics principle were used to test the hypothesis of...

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Identifiers

PMID: 22768937
DOI: 10.1016/j.bpj.2012.03.032
PMCID: PMC3328696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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