Article

Mechanistic insights into volatile anesthetic modulation of K2P channels

2020-06-12

Abstract excerpt

K2P potassium channels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinically relevant effects that accompany general anesthesia. Here, we utilize a photoaffinity analog of the VA isoflurane to identify a VA binding site in the TREK1 K2P channel. The functional importance of the identified site was validated by mutagenesis and biochemical modification. Molecular dynamic...

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Literature Corpus work: 3688b207-88b0-5d1e-a145-69c5f3e26c9d
DOI: 10.1101/2020.06.10.144287

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