Article
A discrete site for general anesthetics on a postsynaptic receptor.
Molecular pharmacology - 1 Oct 1995
Forman S A, Miller K W, Yellen G
Abstract excerpt
General anesthetics depress central nervous system excitability via a mechanism that probably involves effects on synaptic ion channels, but the fundamental molecular nature of the site where they act is unknown. Although the importance of hydrophobicity for general anesthetic drug potency has lo...
Topics
- Amino Acid Sequence
- Anesthetics, General
- Animals
- Binding Sites
- Chemical Phenomena
- Chemistry, Physical
- Female
- Ion Channel Gating
- Ion Channels
- Kinetics
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed