Article

Optimising experimental designs for model selection of ion channel drug binding mechanisms

2024-08-21

Abstract excerpt

The rapid delayed rectifier current carried by the human Ether-à-go-go-Related Gene (hERG) channel is susceptible to drug-induced reduction which can lead to an increased risk of cardiac arrhythmia. Establishing the mechanism by which a specific drug compound binds to hERG can help to reduce uncertainty when quantifying pro-arrhythmic risk. In this study, we introduce a methodology for optimising experimental volt...

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Literature Corpus work: c0faf39a-1c6b-5fdc-a3e4-cde6401414df
DOI: 10.1101/2024.08.20.608856

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