Back to search

Article

Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation

2020-07-29

Abstract excerpt

DNA methylation is a fundamental epigenetic modification regulating gene expression. Aberrant DNA methylation is the most common molecular lesion in cancer cells. However, medical intervention has been limited to the use of toxic, unspecific demethylating drugs. Aptamers are novel high affinity targeting ligand molecules. By conjugating the inherent DNMT1 inhibiting capabilities of RNA to an aptamer platform, we g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b46114b0-d32e-53be-8bb0-289d92ddf690
DOI
10.1101/2020.07.29.226803
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylationDOI 10.1101/2020.07.29.226803
Targeting DNA MethylationSemantic proximity
Antisense Oligonucleotides: Technological Advances, Clinical Progress, and Expanding Therapeutic FrontiersSemantic proximity
Aptamer-Guided Gene Therapy for Cancer DiseaseSemantic proximity
The role of DNA methylation in the pathogenesis and treatment of cancer.Semantic proximity
A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing.Semantic proximity
De novo DNMTs and DNA methylation: novel insights into disease pathogenesis and therapy from epigenomics.Semantic proximity
DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studiesSemantic proximity
Directed evolution of an m6A eraser for site-selective epitranscriptome editingSemantic proximity
The Versatile Applications of Antisense Oligonucleotides in Modern MedicineSemantic proximity
Evolving A RIG-I Antagonist: A Modified DNA Aptamer Mimics Viral RNA.Semantic proximity
Discovery of tumoricidal DNA oligonucleotides by effect-directed <i>in-vitro</i> evolutionSemantic proximity
Direct RNA sequencing enables improved transcriptome assessment and tracking of RNA modifications for medical applicationsSemantic proximity
Select a neighboring publication to make it the new centre.