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Article

Evolving A RIG-I Antagonist: A Modified DNA Aptamer Mimics Viral RNA.

Journal of molecular biology - 15 Oct 2021

Ren Xiaoming, Gelinas Amy D, Linehan Melissa, Iwasaki Akiko, Wang Wenshuai, Janjic Nebojsa, Pyle Anna Marie

Abstract excerpt

Vertebrate organisms express a diversity of protein receptors that recognize and respond to the presence of pathogenic molecules, functioning as an early warning system for infection. As a result of mutation or dysregulated metabolism, these same innate immune receptors can be inappropriately activated, leading to inflammation and disease. One of the most important receptors for detection and response to RNA...

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Share to Antigens, Viral
Share to Aptamers, Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Conformation, alpha-Helical

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Source

Identifiers

PMID: 34487794
DOI: 10.1016/j.jmb.2021.167227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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