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DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies

3 Oct 2012

Abstract excerpt

INTRODUCTION: DNA methylation is an epigenetic modification that modulates gene expression without altering the DNA base sequence. It plays a crucial role in cancer by silencing tumor suppressor genes (TSG). The DNA methyltransferases (DNMT) are the enzymes that catalyze DNA methylation and they are interesting therapeutical targets since DNA methylation is reversible such that an aberrant hypermethylation of DNA...

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PMID: 23033952
DOI: 10.1517/13543776.2012.729579

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