Article

Discovery of tumoricidal DNA oligonucleotides by effect-directed <i>in-vitro</i> evolution

2019-05-07

Abstract excerpt

Our current model of drug discovery is challenged by the relative ineffectiveness of drugs against highly variable and rapidly evolving diseases and their relatively high incidence of adverse effects due to poor selectivity. Here we describe a robust and reproducible platform which could potentially address these limitations. The platform enables rapid, de-novo discovery of DNA oligonucleotides evolved in-vitro...

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Literature Corpus work: 1982d58a-ed26-529f-93c7-2699ac14d15a
DOI: 10.1101/629105

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