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Article

A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing.

Nature chemistry - 1 Nov 2022

Taylor Alexander I, Wan Christopher J K, Donde Maria J, Peak-Chew Sew-Yeu, Holliger Philipp

Abstract excerpt

Nucleic-acid catalysts (ribozymes, DNA- and XNAzymes) cleave target (m)RNAs with high specificity but have shown limited efficacy in clinical applications. Here we report on the in vitro evolution and engineering of a highly specific modular RNA endonuclease XNAzyme, FR6_1, composed of 2'-deoxy-2'-fluoro-β-D-arabino nucleic acid (FANA). FR6_1 overcomes the activity limitations of previous DNA- and XNAzymes and...

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Identifiers

PMID: 36064973
DOI: 10.1038/s41557-022-01021-z
PMCID: PMC7613789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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