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Article

De novo DNMTs and DNA methylation: novel insights into disease pathogenesis and therapy from epigenomics.

Current pharmaceutical design - 1 Jan 2014

Leppert Sylwia, Matarazzo Maria R

Abstract excerpt

DNA methylation plays an important role in epigenetics signaling, having an impact on gene regulation, chromatin structure and development. Within the family of de novo DNA methyltransferases two active enzymes, DNMT3A and DNMT3B, are responsible for the establishment of the proper cytosine methylation profile during development. Defects in DNMT3s function correlate with pathogenesis and progression of monogenic...

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Identifiers

PMID: 23888951
DOI: 10.2174/13816128113199990534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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