The Versatile Applications of Antisense Oligonucleotides in Modern Medicine

Abstract excerpt

Antisense oligonucleotides (ASOs) are a class of nucleic acid therapeutics that modulate gene expression through diverse mechanisms. Since their initial demonstration in inhibiting viral genes, advances in medicinal chemistry, pharmacology, and delivery have enabled robust and durable target engagement across multiple tissues. Chemical modifications to the backbone, ribose, and nucleobases have improved nuclease r...

Topics

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• CRISPR and Genetic Engineering
• DNA and Nucleic Acid Chemistry
• Neurogenetic and Muscular Disorders Research
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• RNA Research and Splicing
• Viral Infections and Immunology Research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

6fd63324-d80c-55da-aeae-5ce26c457605

DOI

10.20944/preprints202605.0825.v1