Antisense Oligonucleotides: Technological Advances, Clinical Progress, and Expanding Therapeutic Frontiers

Abstract excerpt

Antisense oligonucleotides (ASOs) are emerging therapeutic agents that modulate gene expression at the RNA level, offering distinct therapeutic advantages over conventional small-molecule drugs and biologics. By directly targeting RNA, ASOs expand the spectrum of druggable targets to include those previously considered "undruggable" and enable shorter development timelines with improved research and deve...

Topics

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• Cytomegalovirus and herpesvirus research
• DNA and Nucleic Acid Chemistry
• Neurogenetic and Muscular Disorders Research
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• RNA Research and Splicing
• Viral Infections and Immunology Research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

f9c83f9e-c08f-5f8c-9199-5c60b38e1db9

DOI

10.20944/preprints202603.1165.v1