Article

Prevention and reversion of pancreatic tumorigenesis through a differentiation-based mechanism

2017-11-19

Abstract excerpt

<h4>SUMMARY</h4> Activating mutations in Kras are nearly ubiquitous in human pancreatic cancer and initiate precancerous pancreatic intraepithelial neoplasia (PanINs) when induced in adult murine acinar cells. PanINs normally take months to form, but can be rapidly induced by genetic deletion of acinar cell differentiation factors such as Ptf1a , suggesting that loss of mature cell identity is a rate-limiting s...

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Literature Corpus work: b441929e-c5ff-550d-a7e7-5d3c7a18bea0
DOI: 10.1101/221986

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