Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis.

doi:10.1126/science.abj0486

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Article

Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis.

Science (New York, N.Y.) - 17 Sept 2021

Del Poggetto Edoardo, Ho I-Lin, Balestrieri Chiara, Yen Er-Yen, Zhang Shaojun, Citron Francesca, Shah Rutvi, Corti Denise, Diaferia Giuseppe R, Li Chieh-Yuan, Loponte Sara, Carbone Federica, Hayakawa Yoku, Valenti Giovanni, Jiang Shan, Sapio Luigi, Jiang Hong, Dey Prasenjit, Gao Sisi, Deem Angela K, Rose-John Stefan, Yao Wantong, Ying Haoqiang, Rhim Andrew D, Genovese Giannicola, Heffernan Timothy P, Maitra Anirban, Wang Timothy C, Wang Linghua, Draetta Giulio F, Carugo Alessandro, Natoli Gioacchino, Viale Andrea

Abstract excerpt

Inflammation is a major risk factor for pancreatic ductal adenocarcinoma (PDAC). When occurring in the context of pancreatitis, KRAS mutations accelerate tumor development in mouse models. We report that long after its complete resolution, a transient inflammatory event primes pancreatic epithelial cells to subsequent transformation by oncogenic KRAS. Upon recovery from acute inflammation, pancreatic epithelial...

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Identifiers

PMID: 34529467
DOI: 10.1126/science.abj0486
PMCID: PMC9733946

Genes

KRAS
ADM

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