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Article

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.

Nature communications - 20 Feb 2015

Liou Geou-Yarh, Döppler Heike, Braun Ursula B, Panayiotou Richard, Scotti Buzhardt Michele, Radisky Derek C, Crawford Howard C, Fields Alan P, Murray Nicole R, Wang Q Jane, Leitges Michael, Storz Peter

Abstract excerpt

The transdifferentiation of pancreatic acinar cells to a ductal phenotype (acinar-to-ductal metaplasia, ADM) occurs after injury or inflammation of the pancreas and is a reversible process. However, in the presence of activating Kras mutations or persistent epidermal growth factor receptor (EGF-R...

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Source

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Identifiers

PMID: 25698580
DOI: 10.1038/ncomms7200
PMCID: PMC4394184

Genes

ADM
EGF
PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25698580-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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