Article
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
Cancer cell - 1 Dec 2003
Hingorani Sunil R, Petricoin Emanuel F, Maitra Anirban, Rajapakse Vinodh, King Catrina, Jacobetz Michael A, Ross Sally, Conrads Thomas P, Veenstra Timothy D, Hitt Ben A, Kawaguchi Yoshiya, Johann Don, Liotta Lance A, Crawford Howard C, Putt Mary E, Jacks Tyler, Wright Christopher V E, Hruban Ralph H, Lowy Andrew M, Tuveson David A
Abstract excerpt
To evaluate the role of oncogenic RAS mutations in pancreatic tumorigenesis, we directed endogenous expression of KRAS(G12D) to progenitor cells of the mouse pancreas. We find that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer. The PanINs are highly...
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